Large-Fragment Deletions Induced by Cas9 Cleavage while Not in the BEs System

CRISPR-Cas9 and base editors (BEs) systems are poised to become the gene-editing tool of choice in clinical contexts; however, large-fragment deletion was found in Cas9-mediated mutation cells and mice. In this study, by analyzing 16 gene-edited rabbit lines (including 112 rabbits) generated using S...

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Veröffentlicht in:Mol Ther Nucleic Acids
Hauptverfasser: Song, Yuning, Liu, Zhiquan, Zhang, Yuxin, Chen, Mao, Sui, Tingting, Lai, Liangxue, Li, Zhanjun
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Gene & Cell Therapy 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7381496/
https://ncbi.nlm.nih.gov/pubmed/32711379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2020.06.019
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