Development of a brain-permeable peptide nanofiber that prevents aggregation of Alzheimer pathogenic proteins

Alzheimer's disease (AD) is proposed to be induced by abnormal aggregation of amyloidβ in the brain. Here, we designed a brain-permeable peptide nanofiber drug from a fragment of heat shock protein to suppress aggregation of the pathogenic proteins. To facilitate delivery of the nanofiber into...

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Bibliografische gegevens
Gepubliceerd in:PLoS One
Hoofdauteurs: Tanaka, Naoki, Okuda, Michiaki, Nishigaki, Tatsutoshi, Tsuchiya, Nobuhiko, Kobayashi, Yukako, Uemura, Takuya, Kumo, Sayaka, Sugimoto, Hachiro, Miyata, Seiji, Waku, Tomonori
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2020
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7380640/
https://ncbi.nlm.nih.gov/pubmed/32706773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0235979
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