Distinct roles of structure-specific endonucleases EEPD1 and Metnase in replication stress responses

Accurate DNA replication and segregation are critical for maintaining genome integrity and suppressing cancer. Metnase and EEPD1 are DNA damage response (DDR) proteins frequently dysregulated in cancer and implicated in cancer etiology and tumor response to genotoxic chemo- and radiotherapy. Here, w...

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Detalhes bibliográficos
Publicado no:NAR Cancer
Main Authors: Sharma, Neelam, Speed, Michael C, Allen, Christopher P, Maranon, David G, Williamson, Elizabeth, Singh, Sudha, Hromas, Robert, Nickoloff, Jac A
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
DNA Damage Sensing and Repair
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7380491/
https://ncbi.nlm.nih.gov/pubmed/32743552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/narcan/zcaa008
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