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Exposing Hidden High-Affinity RNA Conformational States

RNA recognition frequently results in conformational changes that optimize intermolecular binding. As a consequence, the overall binding affinity of RNA to its binding partners depends not only on the intermolecular interactions formed in the bound state but also on the energy cost associated with c...

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Detalles Bibliográficos
Publicado en:J Am Chem Soc
Main Authors: Orlovsky, Nicole I., Al-Hashimi, Hashim M., Oas, Terrence G.
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7380322/
https://ncbi.nlm.nih.gov/pubmed/31815464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b10535
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