Native Mass Spectrometry Can Effectively Predict PROTAC Efficacy

[Image: see text] Protein degraders, also known as proteolysis targeting chimeras (PROTACs), are bifunctional small molecules that promote cellular degradation of a protein of interest (POI). PROTACs act as molecular mediators, bringing an E3 ligase and a POI into proximity, thus promoting ubiquitin...

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Bibliographic Details
Published in:ACS Cent Sci
Main Authors: Beveridge, Rebecca, Kessler, Dirk, Rumpel, Klaus, Ettmayer, Peter, Meinhart, Anton, Clausen, Tim
Format: Artigo
Language:Inglês
Published: American Chemical Society 2020
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7379389/
https://ncbi.nlm.nih.gov/pubmed/32724856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.0c00049
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