Pharmacokinetics of multivesicular liposomal encapsulated cytarabine when administered subcutaneously in dogs

BACKGROUND: Prolonged cytotoxic concentrations of cytarabine (CA) are required for maximum cytotoxicity. DepoCyt is a human liposomal cytarabine (LC) product that lasts longer in plasma and CSF compared with free CA (FC). The use of LC has not been evaluated in dogs. OBJECTIVES: To perform a LC phar...

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Detalhes bibliográficos
Publicado no:J Vet Intern Med
Main Authors: Vazquez Fuster, Irene B., Taylor, Amanda R., Smith, Annette N., Duran, Sue H., Ravis, William R., Jasper, Shanese L., Arnold, Robert D.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Inc. 2020
Assuntos:
SMALL ANIMAL
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7379012/
https://ncbi.nlm.nih.gov/pubmed/32442344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jvim.15809
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