The gut microbial metabolite trimethylamine N-oxide aggravates GVHD by inducing M1 macrophage polarization in mice

The diversity of the human microbiome heralds the difference of the impact that gut microbial metabolites exert on allogenic graft-versus-host (GVH) disease (GVHD), even though short-chain fatty acids and indole were demonstrated to reduce its severity. In this study, we dissected the role of cholin...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Wu, Kunpeng, Yuan, Yan, Yu, Huihui, Dai, Xin, Wang, Shu, Sun, Zhengxu, Wang, Fen, Fei, He, Lin, Qiwang, Jiang, Hua, Chen, Tong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Transplantation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7378459/
https://ncbi.nlm.nih.gov/pubmed/32291445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019003990
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