PI3K-targeting strategy using alpelisib to enhance the antitumor effect of paclitaxel in human gastric cancer

PIK3CA mutations are frequently observed in various human cancers including gastric cancer (GC). This study was conducted to investigate the anti-tumor effects of alpelisib, a PI3K p110α-specific inhibitor, using preclinical models of GC. In addition, the combined effects of alpelisib and paclitaxel...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Sci Rep
Egile Nagusiak: Kim, Kui-Jin, Kim, Ji-Won, Sung, Ji Hea, Suh, Koung Jin, Lee, Ji Yun, Kim, Se Hyun, Lee, Jeong-Ok, Kim, Jin Won, Kim, Yu Jung, Kim, Jee Hyun, Bang, Soo-Mee, Lee, Jong Seok, Kim, Hark Kyun, Lee, Keun-Wook
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2020
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7378194/
https://ncbi.nlm.nih.gov/pubmed/32704014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-68998-w
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