PI3K-targeting strategy using alpelisib to enhance the antitumor effect of paclitaxel in human gastric cancer

PIK3CA mutations are frequently observed in various human cancers including gastric cancer (GC). This study was conducted to investigate the anti-tumor effects of alpelisib, a PI3K p110α-specific inhibitor, using preclinical models of GC. In addition, the combined effects of alpelisib and paclitaxel...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Kim, Kui-Jin, Kim, Ji-Won, Sung, Ji Hea, Suh, Koung Jin, Lee, Ji Yun, Kim, Se Hyun, Lee, Jeong-Ok, Kim, Jin Won, Kim, Yu Jung, Kim, Jee Hyun, Bang, Soo-Mee, Lee, Jong Seok, Kim, Hark Kyun, Lee, Keun-Wook
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2020
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7378194/
https://ncbi.nlm.nih.gov/pubmed/32704014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-68998-w
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