Prophylactic treatment with transdermal deferoxamine mitigates radiation-induced skin fibrosis

Radiation therapy can result in pathological fibrosis of healthy soft tissue. The iron chelator deferoxamine (DFO) has been shown to improve skin vascularization when injected into radiated tissue prior to fat grafting. Here, we evaluated whether topical DFO administration using a transdermal drug d...

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Pubblicato in:Sci Rep
Autori principali: Shen, Abra H., Borrelli, Mimi R., Adem, Sandeep, Deleon, Nestor M. Diaz, Patel, Ronak A., Mascharak, Shamik, Yen, Sara J., Sun, Blake Y., Taylor, Walter L., Januszyk, Michael, Nguyen, Dung H., Momeni, Arash, Gurtner, Geoffrey C., Longaker, Michael T., Wan, Derrick C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7378074/
https://ncbi.nlm.nih.gov/pubmed/32704071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-69293-4
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