Prophylactic treatment with transdermal deferoxamine mitigates radiation-induced skin fibrosis

Radiation therapy can result in pathological fibrosis of healthy soft tissue. The iron chelator deferoxamine (DFO) has been shown to improve skin vascularization when injected into radiated tissue prior to fat grafting. Here, we evaluated whether topical DFO administration using a transdermal drug d...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Shen, Abra H., Borrelli, Mimi R., Adem, Sandeep, Deleon, Nestor M. Diaz, Patel, Ronak A., Mascharak, Shamik, Yen, Sara J., Sun, Blake Y., Taylor, Walter L., Januszyk, Michael, Nguyen, Dung H., Momeni, Arash, Gurtner, Geoffrey C., Longaker, Michael T., Wan, Derrick C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7378074/
https://ncbi.nlm.nih.gov/pubmed/32704071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-69293-4
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