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A novel knock out strategy to enhance recombinant protein expression in Escherichia coli
BACKGROUND: The expression of recombinant proteins triggers a stress response which downregulates key metabolic pathway genes leading to a decline in cellular health and feedback inhibition of both growth and protein expression. Instead of individually upregulating these downregulated genes or impro...
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| Udgivet i: | Microb Cell Fact |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
BioMed Central
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7376861/ https://ncbi.nlm.nih.gov/pubmed/32703203 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-020-01407-z |
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