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Separation and Quantification of Superwarfarin Rodenticide Diastereomers—Bromadiolone, Difenacoum, Flocoumafen, Brodifacoum, and Difethialone—in Human Plasma

BACKGROUND: Superwarfarins, second-generation long-acting anticoagulant rodenticides, are 4-hydroxycoumarin analogues of warfarin that contain a large hydrophobic side chain. These compounds contain two chiral centers and are synthesized for commercial use as two pairs of diastereomer. OBJECTIVE: To...

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Detalhes bibliográficos
Publicado no:J AOAC Int
Main Authors: Nosal, Daniel G, Feinstein, Douglas L, Chen, Luying, van Breemen, Richard B
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7372953/
https://ncbi.nlm.nih.gov/pubmed/33241367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jaoacint/qsaa007
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