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Functional Validation of CLDN Variants Identified in a Neural Tube Defect Cohort Demonstrates Their Contribution to Neural Tube Defects

Neural tube defects (NTDs) are severe malformations of the central nervous system that affect 1–2 individuals per 2,000 births. Their etiology is complex and involves both genetic and environmental factors. Our recent discovery that simultaneous removal of Cldn3, -4, and -8 from tight junctions resu...

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Publicat a:Front Neurosci
Autors principals: Baumholtz, Amanda I., De Marco, Patrizia, Capra, Valeria, Ryan, Aimee K.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2020
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7372130/
https://ncbi.nlm.nih.gov/pubmed/32760237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2020.00664
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