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Functional Validation of CLDN Variants Identified in a Neural Tube Defect Cohort Demonstrates Their Contribution to Neural Tube Defects

Neural tube defects (NTDs) are severe malformations of the central nervous system that affect 1–2 individuals per 2,000 births. Their etiology is complex and involves both genetic and environmental factors. Our recent discovery that simultaneous removal of Cldn3, -4, and -8 from tight junctions resu...

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Vydáno v:Front Neurosci
Hlavní autoři: Baumholtz, Amanda I., De Marco, Patrizia, Capra, Valeria, Ryan, Aimee K.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7372130/
https://ncbi.nlm.nih.gov/pubmed/32760237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2020.00664
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