Failed Genetic Protection: Type 1 Diabetes in the Presence of HLA-DQB1*06:02

Certain HLA class II genes increase the risk for type 1 diabetes (T1D) development while others provide protection from disease development. HLA class II alleles encode MHC proteins on antigen-presenting cells, which function to present peptides and activate CD4 T cells. The DRB1*15:01 (DR15)-DQA1*0...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Simmons, Kimber M., Mitchell, Angela M., Alkanani, Aimon A., McDaniel, Kristen A., Baschal, Erin E., Armstrong, Taylor, Pyle, Laura, Yu, Liping, Michels, Aaron W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2020
Assuntos:
Immunology and Transplantation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7372070/
https://ncbi.nlm.nih.gov/pubmed/32439825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db20-0038
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