Tanshinone IIA Promotes Axonal Regeneration in Rats with Focal Cerebral Ischemia Through the Inhibition of Nogo-A/NgR1/RhoA/ROCKII/MLC Signaling

PURPOSE: The aim of this study was to evaluate the neuroprotective effect of tanshinone IIA (TSA) on focal cerebral ischemia in rats and to investigate whether it was associated with Nogo-A/NgR1/RhoA/Rho-associated protein kinase 2 (ROCKII)/myosin light chain (MLC) signaling. METHODS: In this study,...

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Publicat a:Drug Des Devel Ther
Autors principals: Wang, Jing, Ni, Guangxiao, Liu, Yanming, Han, Ying, Jia, Lin, Wang, Yali
Format: Artigo
Idioma:Inglês
Publicat: Dove 2020
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7371607/
https://ncbi.nlm.nih.gov/pubmed/32764877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S253280
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