Mithramycin suppresses DNA damage repair via targeting androgen receptor in prostate cancer

The dependency of prostate cancer (PCa) growth on androgen receptor (AR) signaling has been harnessed to develop first-line therapies for high-risk localized and metastatic PCa treatment. However, the occurrence of aberrant expression, mutated or splice variants of AR confers resistance to androgen...

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Udgivet i:Cancer Lett
Main Authors: Wang, Shan, Gilbreath, Collin, Kollipara, Rahul K., Sonavane, Rajni, Huo, Xiaofang, Yenerall, Paul, Das, Amit, Ma, Shihong, Raj, Ganesh V., Kittler, Ralf
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7370677/
https://ncbi.nlm.nih.gov/pubmed/32485222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2020.05.027
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