Synthesis of cyclophosphamide metabolites by a peroxygenase from Marasmius rotula for toxicological studies on human cancer cells

Cyclophosphamide (CPA) represents a widely used anti-cancer prodrug that is converted by liver cytochrome P450 (CYP) enzymes into the primary metabolite 4-hydroxycyclophosphamide (4-OH-CPA), followed by non-enzymatic generation of the bioactive metabolites phosphoramide mustard and acrolein. The use...

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Publicado en:AMB Express
Autores principales: Steinbrecht, Susanne, Kiebist, Jan, König, Rosalie, Thiessen, Markus, Schmidtke, Kai-Uwe, Kammerer, Sarah, Küpper, Jan-Heiner, Scheibner, Katrin
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer Berlin Heidelberg 2020
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7368878/
https://ncbi.nlm.nih.gov/pubmed/32683510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13568-020-01064-w
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