A lipocalin mediates unidirectional heme biomineralization in malaria parasites

During blood-stage development, malaria parasites are challenged with the detoxification of enormous amounts of heme released during the proteolytic catabolism of erythrocytic hemoglobin. They tackle this problem by sequestering heme into bioinert crystals known as hemozoin. The mechanisms underlyin...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Matz, Joachim M., Drepper, Benjamin, Blum, Thorsten B., van Genderen, Eric, Burrell, Alana, Martin, Peer, Stach, Thomas, Collinson, Lucy M., Abrahams, Jan Pieter, Matuschewski, Kai, Blackman, Michael J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2020
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7368307/
https://ncbi.nlm.nih.gov/pubmed/32601225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2001153117
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