Structural basis for the broad substrate specificity of two acyl-CoA dehydrogenases FadE5 from mycobacteria

FadE, an acyl-CoA dehydrogenase, introduces unsaturation to carbon chains in lipid metabolism pathways. Here, we report that FadE5 from Mycobacterium tuberculosis (MtbFadE5) and Mycobacterium smegmatis (MsFadE5) play roles in drug resistance and exhibit broad specificity for linear acyl-CoA substrat...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Chen, Xiaobo, Chen, Jiayue, Yan, Bing, Zhang, Wei, Guddat, Luke W., Liu, Xiang, Rao, Zihe
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2020
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7368279/
https://ncbi.nlm.nih.gov/pubmed/32601219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2002835117
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