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Attenuation of cGAS/STING activity during mitosis
The innate immune system recognizes cytosolic DNA associated with microbial infections and cellular stress via the cGAS/STING pathway, leading to activation of phospho-IRF3 and downstream IFN-I and senescence responses. To prevent hyperactivation, cGAS/STING is presumed to be nonresponsive to chromo...
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| Published in: | Life Sci Alliance |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Life Science Alliance LLC
2020
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7368095/ https://ncbi.nlm.nih.gov/pubmed/32661021 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.201900636 |
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