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Can Denosumab be used in combination with Doxorubicin in Osteosarcoma?

Osteosarcoma is an aggressive bone tumor of the pediatric age. It is therefore important to improve conventional therapies (chemotherapy and surgery). Anticancer drugs often cause osteoporosis due to a misbalance of RANK/RANK-L/OPG pathway. Denosumab is a monoclonal antibody with high affinity and s...

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Bibliografske podrobnosti
izdano v:Oncotarget
Main Authors: Punzo, Francesca, Tortora, Chiara, Argenziano, Maura, Pinto, Daniela Di, Pota, Elvira, Martino, Martina Di, Paola, Alessandra Di, Rossi, Francesca
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7367655/
https://ncbi.nlm.nih.gov/pubmed/32733647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27669
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