Bacteria pathogens drive host colonic epithelial cell promoter hypermethylation of tumor suppressor genes in colorectal cancer

BACKGROUND: Altered microbiome composition and aberrant promoter hypermethylation of tumor suppressor genes (TSGs) are two important hallmarks of colorectal cancer (CRC). Here we performed concurrent 16S rRNA gene sequencing and methyl-CpG binding domain-based capture sequencing in 33 tissue biopsie...

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Vydáno v:Microbiome
Hlavní autoři: Xia, Xiaoxuan, Wu, William Ka Kei, Wong, Sunny Hei, Liu, Dabin, Kwong, Thomas Ngai Yeung, Nakatsu, Geicho, Yan, Pearlly S., Chuang, Yu-Ming, Chan, Michael Wing-Yan, Coker, Olabisi Oluwabukola, Chen, Zigui, Yeoh, Yun Kit, Zhao, Liuyang, Wang, Xiansong, Cheng, Wing Yin, Chan, Matthew Tak Vai, Chan, Paul Kay Sheung, Sung, Joseph Jao Yiu, Wang, Maggie Haitian, Yu, Jun
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2020
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7367367/
https://ncbi.nlm.nih.gov/pubmed/32678024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40168-020-00847-4
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