G-quadruplexes offer a conserved structural motif for NONO recruitment to NEAT1 architectural lncRNA

The long non-coding RNA NEAT1 serves as a scaffold for the assembly of paraspeckles, membraneless nuclear organelles involved in gene regulation. Paraspeckle assembly requires NEAT1 recruitment of the RNA-binding protein NONO, however the NEAT1 elements responsible for recruitment are unknown. Herei...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Simko, Eric A J, Liu, Honghe, Zhang, Tao, Velasquez, Adan, Teli, Shraddha, Haeusler, Aaron R, Wang, Jiou
Format: Artigo
Language:Inglês
Published: Oxford University Press 2020
Subjects:
RNA and RNA-protein complexes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7367201/
https://ncbi.nlm.nih.gov/pubmed/32496517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa475
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