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Pathway and mechanism of drug binding to chemokine receptors revealed by accelerated molecular simulations
BACKGROUND: Chemokine GPCRs play key roles in biology and medicine. Particularly, CXCR4 promotes cancer metastasis and facilitate HIV entry into host cells. Plerixafor (PLX) is a CXCR4 drug, but the pathway and binding site of PLX in CXCR4 remain unknown. RESULTS & METHODOLOGY: We have performed...
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| Yayımlandı: | Future Med Chem |
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| Asıl Yazarlar: | , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Newlands Press Ltd
2020
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7367101/ https://ncbi.nlm.nih.gov/pubmed/32515227 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4155/fmc-2020-0044 |
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