The integrity of cochlear hair cells is established and maintained through the localization of Dia1 at apical junctional complexes and stereocilia

Dia1, which belongs to the diaphanous-related formin family, influences a variety of cellular processes through straight actin elongation activity. Recently, novel DIA1 mutants such as p.R1213X (p.R1204X) and p.A265S, have been reported to cause an autosomal dominant sensorineural hearing loss (DFNA...

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Bibliografske podrobnosti
izdano v:Cell Death Dis
Main Authors: Ninoyu, Yuzuru, Sakaguchi, Hirofumi, Lin, Chen, Suzuki, Toshiaki, Hirano, Shigeru, Hisa, Yasuo, Saito, Naoaki, Ueyama, Takehiko
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2020
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7366933/
https://ncbi.nlm.nih.gov/pubmed/32678080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-02743-z
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