Berberine Ameliorates Subarachnoid Hemorrhage Injury via Induction of Sirtuin 1 and Inhibiting HMGB1/Nf-κB Pathway

Excessive cerebral inflammation plays a key role in early brain injury (EBI) after subarachnoid hemorrhage (SAH). Berberine, an isoquinoline alkaloid isolated from Chinese herb Coptis chinensis, possesses anti-inflammatory, and neuroprotective effects. Here we evaluated the beneficial effects of ber...

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Bibliographische Detailangaben
Veröffentlicht in:Front Pharmacol
Hauptverfasser: Zhang, Xiang-Hua, Peng, Lei, Zhang, Jing, Dong, Yi-Peng, Wang, Cheng-Jun, Liu, Cang, Xia, Da-Yong, Zhang, Xiang-Sheng
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7366844/
https://ncbi.nlm.nih.gov/pubmed/32754040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.01073
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