Letrozole Rat Model Mimics Human Polycystic Ovarian Syndrome and Changes in Insulin Signal Pathways

BACKGROUND: The aim of this study was to explore whether letrozole and high-fat diets (HFD) can induce obese insulin-resistant polycystic ovary syndrome (PCOS) with all reproductive and metabolic phenotypes in a rat model. MATERIAL/METHODS: Twenty-four 3-week-old female Sprague-Dawley rats were rand...

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Detalhes bibliográficos
Publicado no:Med Sci Monit
Main Authors: Xu, Jinbang, Dun, Jingjing, Yang, Juan, Zhang, Junxin, Lin, Qiuping, Huang, Mingqing, Ji, Feng, Huang, Lishan, You, Xiumi, Lin, Ying
Formato: Artigo
Idioma:Inglês
Publicado em: International Scientific Literature, Inc. 2020
Assuntos:
Animal Study
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7366789/
https://ncbi.nlm.nih.gov/pubmed/32638705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12659/MSM.923073
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