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双靶点嵌合抗原受体T细胞治疗CD19抗原表位缺失急性B淋巴细胞白血病一例报告并文献复习

OBJECTIVE: To analyze the influence of CD19 isoforms to the efficacy of CD19/CD3 Bispecific T-cell Engager (BiTE) antibody, and explore the resistance mechanism of BiTE immunotherapy. METHODS: Semi-quantitative RT-PCR (qRT-PCR) was used to detect the expression of CD19 mRNA isoforms before and after...

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Bibliografiset tiedot
Julkaisussa:Zhonghua Xue Ye Xue Za Zhi
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Editorial office of Chinese Journal of Hematology 2020
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7364923/
https://ncbi.nlm.nih.gov/pubmed/32447930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3760/cma.j.issn.0253-2727.2020.04.004
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