A high enantiomeric excess in-loop synthesis of D-[methyl-(11)C]methionine for use as a diagnostic PET radiotracer in bacterial infection

Currently, there exists no accurate, non-invasive clinical imaging method to detect living bacteria in vivo. Our goal is to provide a positron emission tomography (PET) method to image infection by targeting bacteria-specific metabolism. Standard of care methodologies either detect morphologic chang...

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Detalhes bibliográficos
Publicado no:ACS Infect Dis
Main Authors: Stewart, Megan N., Parker, Matthew F. L., Jivan, Salma, Luu, Justin M., Huynh, Tony L., Schulte, Brailee, Seo, Youngho, Blecha, Joseph E., Villanueva-Meyer, Javier, Flavell, Robert R., VanBrocklin, Henry, Ohliger, Michael, Rosenberg, Oren, Wilson, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7364312/
https://ncbi.nlm.nih.gov/pubmed/31697062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.9b00196
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