Inhibition of ABL1 tyrosine kinase reduces HTLV-1 proviral loads in peripheral blood mononuclear cells from patients with HTLV-1-associated myelopathy/tropical spastic paraparesis

Human T-cell leukemia virus type 1 (HTLV-1) causes incurable adult T-cell leukemia and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Patients with HAM/TSP have increased levels of HTLV-1-infected cells compared with asymptomatic HTLV-1 carriers. However, the roles of cellular...

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Udgivet i:PLoS Negl Trop Dis
Main Authors: Kodama, Daisuke, Tanaka, Masakazu, Matsuzaki, Toshio, Izumo, Kimiko, Nakano, Nobuaki, Matsuura, Eiji, Saito, Mineki, Nagai, Masahiro, Horiuchi, Masahisa, Utsunomiya, Atae, Takashima, Hiroshi, Kubota, Ryuji, Izumo, Shuji
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7363079/
https://ncbi.nlm.nih.gov/pubmed/32667912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0008361
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