The unfolded protein response is activated in the olfactory system in Alzheimer’s disease

Olfactory dysfunction is an early and prevalent symptom of Alzheimer’s disease (AD) and the olfactory bulb is a nexus of beta-amyloid plaque and tau neurofibrillary tangle (NFT) pathology during early AD progression. To mitigate the accumulation of misfolded proteins, an endoplasmic reticulum stress...

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Vydáno v:Acta Neuropathol Commun
Hlavní autoři: Murray, Helen C., Dieriks, Birger Victor, Swanson, Molly E. V., Anekal, Praju Vikas, Turner, Clinton, Faull, Richard L. M., Belluscio, Leonardo, Koretsky, Alan, Curtis, Maurice A.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2020
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7362534/
https://ncbi.nlm.nih.gov/pubmed/32665027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-00986-7
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