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Enhanced axonal response of mitochondria to demyelination offers neuroprotection: implications for multiple sclerosis

Axonal loss is the key pathological substrate of neurological disability in demyelinating disorders, including multiple sclerosis (MS). However, the consequences of demyelination on neuronal and axonal biology are poorly understood. The abundance of mitochondria in demyelinated axons in MS raises th...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol
Main Authors: Licht-Mayer, Simon, Campbell, Graham R., Canizares, Marco, Mehta, Arpan R., Gane, Angus B., McGill, Katie, Ghosh, Aniket, Fullerton, Alexander, Menezes, Niels, Dean, Jasmine, Dunham, Jordon, Al-Azki, Sarah, Pryce, Gareth, Zandee, Stephanie, Zhao, Chao, Kipp, Markus, Smith, Kenneth J., Baker, David, Altmann, Daniel, Anderton, Stephen M., Kap, Yolanda S., Laman, Jon D., Hart, Bert A.‘t, Rodriguez, Moses, Watzlawick, Ralf, Schwab, Jan M., Carter, Roderick, Morton, Nicholas, Zagnoni, Michele, Franklin, Robin J. M., Mitchell, Rory, Fleetwood-Walker, Sue, Lyons, David A., Chandran, Siddharthan, Lassmann, Hans, Trapp, Bruce D., Mahad, Don J.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7360646/
https://ncbi.nlm.nih.gov/pubmed/32572598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-020-02179-x
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