The Monoclonal Antibody NEO-201 Enhances Natural Killer Cell Cytotoxicity Against Tumor Cells Through Blockade of the Inhibitory CEACAM5/CEACAM1 Immune Checkpoint Pathway

Background: Natural killer (NK) cells are essential to innate immunity and participate in cancer immune surveillance. Heterophilic interactions between carcinoembryonic antigen (CEA) on tumor cells and carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) on NK cells inhibit NK cell cy...

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Detalhes bibliográficos
Publicado no:Cancer Biother Radiopharm
Main Authors: Fantini, Massimo, David, Justin M., Annunziata, Christina M., Morelli, Maria Pia, Arlen, Phillip M., Tsang, Kwong Y.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc., publishers 2020
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7360111/
https://ncbi.nlm.nih.gov/pubmed/31928422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/cbr.2019.3141
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