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The mevalonate pathway is an actionable vulnerability of t(4;14)-positive multiple myeloma
Multiple myeloma (MM) is a plasma cell malignancy that is often driven by chromosomal translocations. In particular, patients with t(4;14)-positive disease have worse prognosis compared to other MM subtypes. Herein, we demonstrated that t(4;14)-positive cells are highly dependent on the mevalonate (...
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| 出版年: | Leukemia |
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| 主要な著者: | , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7359767/ https://ncbi.nlm.nih.gov/pubmed/32665698 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-020-0962-2 |
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