The choline transporter Slc44a2 controls platelet activation and thrombosis by regulating mitochondrial function

Genetic factors contribute to the risk of thrombotic diseases. Recent genome wide association studies have identified genetic loci including SLC44A2 which may regulate thrombosis. Here we show that Slc44a2 controls platelet activation and thrombosis by regulating mitochondrial energetics. We find th...

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Pubblicato in:Nat Commun
Autori principali: Bennett, J. Allen, Mastrangelo, Michael A., Ture, Sara K., Smith, Charles O., Loelius, Shannon G., Berg, Rachel A., Shi, Xu, Burke, Ryan M., Spinelli, Sherry L., Cameron, Scott J., Carey, Thomas E., Brookes, Paul S., Gerszten, Robert E., Sabater-Lleal, Maria, de Vries, Paul S., Huffman, Jennifer E., Smith, Nicholas L., Morrell, Craig N., Lowenstein, Charles J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7359028/
https://ncbi.nlm.nih.gov/pubmed/32661250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17254-w
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