Tryptophan Catabolism as Immune Mechanism of Primary Resistance to Anti-PD-1

Background: Clinical trials showed that only a subset of patients benefits from immunotherapy, suggesting the need to identify new predictive biomarker of resistance. Indoleamine-2,3-dioxygenase (IDO) has been proposed as a mechanism of resistance to anti-PD-1 treatment, and serum kynurenine/tryptop...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Botticelli, Andrea, Mezi, Silvia, Pomati, Giulia, Cerbelli, Bruna, Cerbelli, Edoardo, Roberto, Michela, Giusti, Raffaele, Cortellini, Alessio, Lionetto, Luana, Scagnoli, Simone, Zizzari, Ilaria Grazia, Nuti, Marianna, Simmaco, Maurizio, Marchetti, Paolo
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7358280/
https://ncbi.nlm.nih.gov/pubmed/32733441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.01243
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