Alvaxanthone, a Thymidylate Synthase Inhibitor with Nematocidal and Tumoricidal Activities

With the aim to identify novel inhibitors of parasitic nematode thymidylate synthase (TS), we screened in silico an in-house library of natural compounds, taking advantage of a model of nematode TS three-dimensional (3D) structure and choosing candidate compounds potentially capable of enzyme bindin...

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Vydáno v:Molecules
Hlavní autoři: Maj, Piotr, Mori, Mattia, Sobich, Justyna, Markowicz, Joanna, Uram, Łukasz, Zieliński, Zbigniew, Quaglio, Deborah, Calcaterra, Andrea, Cau, Ylenia, Botta, Bruno, Rode, Wojciech
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7356228/
https://ncbi.nlm.nih.gov/pubmed/32586022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25122894
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