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Human Cerebrospinal Fluid Promotes Neuronal Circuit Maturation of Human Induced Pluripotent Stem Cell-Derived 3D Neural Aggregates

Human induced pluripotent stem cell (hiPSC)-derived in vitro neural and organoid models resemble fetal, rather than adult brain properties, indicating that currently applied cultivation media and supplements are insufficient to achieve neural maturation beyond the fetal stage. In vivo, cerebrospinal...

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Veröffentlicht in:Stem Cell Reports
Hauptverfasser: Izsak, Julia, Seth, Henrik, Theiss, Stephan, Hanse, Eric, Illes, Sebastian
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7355159/
https://ncbi.nlm.nih.gov/pubmed/32521247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2020.05.006
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