Methotrexate-Loaded Nanostructured Lipid Carrier Gel Alleviates Imiquimod-Induced Psoriasis by Moderating Inflammation: Formulation, Optimization, Characterization, In-Vitro and In-Vivo Studies

INTRODUCTION: Methotrexate exhibits poor cutaneous bioavailability and systemic side effects on topical administration, so there is an unmet need for a novel carrier and its optimized therapy. Methotrexate-loaded nanostructured lipid carriers (MTXNLCs) were formulated and characterized to determine...

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Detalhes bibliográficos
Publicado no:Int J Nanomedicine
Main Authors: Agrawal, Yogeeta O, Mahajan, Umesh B, Mahajan, Hitendra S, Ojha, Shreesh
Formato: Artigo
Idioma:Inglês
Publicado em: Dove 2020
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7354956/
https://ncbi.nlm.nih.gov/pubmed/32753865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S247007
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