Biosynthesis, Mechanism of Action, and Inhibition of the Enterotoxin Tilimycin Produced by the Opportunistic Pathogen Klebsiella oxytoca

Tilimycin is an enterotoxin produced by the opportunistic pathogen Klebsiella oxytoca that causes antibiotic-associated hemorrhagic colitis (AAHC). This pyrrolobenzodiazepine (PBD) natural product is synthesized by a bimodular nonribosomal peptide synthetase (NRPS) pathway comprised of three protein...

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Bibliografske podrobnosti
izdano v:ACS Infect Dis
Main Authors: Alexander, Evan M., Kreitler, Dale F., Guidolin, Valeria, Hurben, Alexander K., Drake, Eric, Villalta, Peter W., Balbo, Silvia, Gulick, Andrew M., Aldrich, Courtney C.
Format: Artigo
Jezik:Inglês
Izdano: 2020
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7354218/
https://ncbi.nlm.nih.gov/pubmed/32485104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.0c00326
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