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A bench-top automated sputum-to-genotype system using a Lab-on-a-Film assembly for detection of multidrug-resistant Mycobacterium tuberculosis

Automated genotyping of drug-resistant Mycobacterium tuberculosis (MTB) directly from sputum is challenging for three primary reasons. First, the sample matrix – sputum – is highly viscous and heterogeneous, posing a challenge for sample processing. Second, acid-fast MTB bacilli are difficult to lys...

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Détails bibliographiques
Publié dans:Anal Chem
Auteurs principaux: Kukhtin, Alexander V., Norville, Ryan, Bueno, Arial, Qu, Peter, Parrish, Nicole, Murray, Megan, Chandler, Darrell P., Holmberg, Rebecca C., Cooney, Christopher G.
Format: Artigo
Langue:Inglês
Publié: 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7354060/
https://ncbi.nlm.nih.gov/pubmed/32142258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.9b05853
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