Association of Apolipoprotein E in Lipoprotein Subspecies With Risk of Dementia

IMPORTANCE: The ε4 allele of the apolipoprotein E (APOE) gene and lower apolipoprotein E (apoE) protein levels in plasma are risk factors for Alzheimer disease, but the underlying biological mechanisms are not fully understood. Half of plasma apoE circulates on high-density lipoproteins (HDLs). High...

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Détails bibliographiques
Publié dans:JAMA Netw Open
Auteurs principaux: Koch, Manja, DeKosky, Steven T., Goodman, Matthew, Sun, Jiehuan, Furtado, Jeremy D., Fitzpatrick, Annette L., Mackey, Rachel H., Cai, Tianxi, Lopez, Oscar L., Kuller, Lewis H., Mukamal, Kenneth J., Jensen, Majken K.
Format: Artigo
Langue:Inglês
Publié: American Medical Association 2020
Sujets:
Original Investigation
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7352155/
https://ncbi.nlm.nih.gov/pubmed/32648923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamanetworkopen.2020.9250
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