Overexpressed coiled-coil domain containing protein 8 (CCDC8) mediates newly synthesized HIV-1 Gag lysosomal degradation

Normally, HIV-1 enters into CD4+ cells through membrane fusion, and newly synthesized HIV-1 viral proteins assemble on the plasma membrane to form viral particles and bud out. In the previous study, we found host factor coiled-coil domain containing protein 8 (CCDC8) can strongly inhibit HIV-1 produ...

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Publicat a:Sci Rep
Autors principals: Jiang, Xiangxiang, Jia, Xiaopeng, Sun, Jinhuan, Qi, Chunxia, Lu, Lingling, Wang, Yanfeng, Zhang, Lei, Wei, Min
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7351720/
https://ncbi.nlm.nih.gov/pubmed/32651437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-68341-3
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