Assessment of a Model-Informed Precision Dosing Platform Use in Routine Clinical Care for Personalized Busulfan Therapy in the Pediatric Hematopoietic Cell Transplantation (HCT) Population

INTRODUCTION: Population pharmacokinetic (PK) studies demonstrate model-based dosing for busulfan that incorporates body size and age improve clinical target attainment as compared to weight-based regimens. Recently, for clinical dosing of busulfan and TDM, our institution transitioned to a cloud-ba...

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Опубликовано в: :Front Pharmacol
Главные авторы: Shukla, Praveen, Goswami, Srijib, Keizer, Ron J., Winger, Beth Apsel, Kharbanda, Sandhya, Dvorak, Christopher C., Long-Boyle, Janel
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2020
Предметы:
Pharmacology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7351521/
https://ncbi.nlm.nih.gov/pubmed/32714184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00888
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