MKL-1 is a coactivator for STAT5b, the regulator of Treg cell development and function

BACKGROUND: Foxp3(+)CD4(+) regulatory T cells (Treg) constitutes a key event in autoimmune diseases. STAT5b is the critical link between the IL-2/15 and FOXP3, the master regulator of Treg cells. METHODS: The CD3(+)T cell and Foxp3(+)CD4(+) regulatory T cells were overexpressioned or knockdown MKL-1...

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Vydáno v:Cell Commun Signal
Hlavní autoři: Xiang, Yuan, Wang, Jun, Li, Jia Peng, Guo, Wei, Huang, Feng, Zhang, Hui Min, Li, Han Han, Dai, Zhou Tong, Zhang, Zi Jian, Li, Hui, Bao, Le Yuan, Gu, Chao Jiang, Chen, Kun, Zhang, Tong Cun, Liao, Xing Hua
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2020
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7350762/
https://ncbi.nlm.nih.gov/pubmed/32646440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-020-00574-1
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