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Orf Virus-Based Vaccine Vector D1701-V Induces Strong CD8+ T Cell Response against the Transgene but Not against ORFV-Derived Epitopes

The potency of viral vector-based vaccines depends on their ability to induce strong transgene-specific immune response without triggering anti-vector immunity. Previously, Orf virus (ORFV, Parapoxvirus) strain D1701-V was reported as a novel vector mediating protection against viral infections. The...

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Detalhes bibliográficos
Publicado no:Vaccines (Basel)
Main Authors: Reguzova, Alena, Ghosh, Michael, Müller, Melanie, Rziha, Hanns-Joachim, Amann, Ralf
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7349966/
https://ncbi.nlm.nih.gov/pubmed/32531997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/vaccines8020295
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