Deferiprone (DFP) Targets Cancer Stem Cell (CSC) Propagation by Inhibiting Mitochondrial Metabolism and Inducing ROS Production

Deferiprone (DFP), also known as Ferriprox, is an FDA-approved, orally active, iron chelator that is currently used clinically for the treatment of iron-overload, especially in thalassaemia major. As iron is a critical factor in Fe-S cluster assembly that is absolutely required for the metabolic fun...

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Bibliographic Details
Published in:Cells
Main Authors: Fiorillo, Marco, Tóth, Fanni, Brindisi, Matteo, Sotgia, Federica, Lisanti, Michael P.
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7349387/
https://ncbi.nlm.nih.gov/pubmed/32585919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9061529
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