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DNA Hypermethylation and Unstable Repeat Diseases: A Paradigm of Transcriptional Silencing to Decipher the Basis of Pathogenic Mechanisms

Unstable repeat disorders comprise a variable group of incurable human neurological and neuromuscular diseases caused by an increase in the copy number of tandem repeats located in various regions of their resident genes. It has become clear that dense DNA methylation in hyperexpanded non-coding rep...

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Bibliographic Details
Published in:Genes (Basel)
Main Authors: Poeta, Loredana, Drongitis, Denise, Verrillo, Lucia, Miano, Maria Giuseppina
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7348995/
https://ncbi.nlm.nih.gov/pubmed/32580525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/genes11060684
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