Therapeutic vaccine-mediated Gag-specific CD8(+) T-cell induction under anti-retroviral therapy augments anti-virus efficacy of CD8(+) cells in simian immunodeficiency virus-infected macaques

Anti-retroviral therapy (ART) can inhibit HIV proliferation but not achieve virus eradication from HIV-infected individuals. Under ART-based HIV control, virus-specific CD8(+) T-cell responses are often reduced. Here, we investigated the impact of therapeutic vaccination inducing virus-specific CD8(...

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Publicado no:Sci Rep
Main Authors: Nakamura-Hoshi, Midori, Takahara, Yusuke, Matsuoka, Saori, Ishii, Hiroshi, Seki, Sayuri, Nomura, Takushi, Yamamoto, Hiroyuki, Sakawaki, Hiromi, Miura, Tomoyuki, Tokusumi, Tsuyoshi, Shu, Tsugumine, Matano, Tetsuro
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7347614/
https://ncbi.nlm.nih.gov/pubmed/32647227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-68267-w
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