Deletion of IL-6 Exacerbates Colitis and Induces Systemic Inflammation in IL-10-Deficient Mice

BACKGROUND AND AIMS: Interleukin 6 [IL-6] or its receptor is currently a candidate for targeted biological therapy of inflammatory bowel disease [IBD]. Thus, a comprehensive understanding of the consequences of blocking IL-6 is imperative. We investigated this by evaluating the effects of IL-6 delet...

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Veröffentlicht in:J Crohns Colitis
Hauptverfasser: Ye, Mei, Joosse, Maria E, Liu, Ling, Sun, Yu, Dong, Ying, Cai, Changchun, Song, Zhenmei, Zhang, Jennifer, Brant, Steven R, Lazarev, Mark, Li, Xuhang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2020
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7346894/
https://ncbi.nlm.nih.gov/pubmed/31679013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ecco-jcc/jjz176
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