Selective serotonin reuptake inhibitors (SSRIs) prevent meta-iodobenzylguanidine (MIBG) uptake in platelets without affecting neuroblastoma tumor uptake

BACKGROUND: The therapeutic use of [(131)I]meta-iodobenzylguanidine ([(131)I]MIBG) is often accompanied by hematological toxicity, mainly consisting of persistent and severe thrombocytopenia. While MIBG accumulates in neuroblastoma cells via selective uptake by the norepinephrine transporter (NET),...

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Detalhes bibliográficos
Publicado no:EJNMMI Res
Main Authors: Blom, Thomas, Meinsma, Rutger, Rutgers, Marja, Buitenhuis, Corine, Dekken-Van den Burg, Marieke, van Kuilenburg, André B. P., Tytgat, Godelieve A. M.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2020
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7343696/
https://ncbi.nlm.nih.gov/pubmed/32642907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13550-020-00662-w
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